Abstract
Xylarenones C-E (2-4), three new eremophilane sesquiterpenes, have been isolated from solid substrate cultures of a Camarops-like endophytic fungus isolated from Alibertia macrophylla. The structures were elucidated by analysis of spectroscopic data. Compounds were evaluated in subtilisin and pepsin protease assays, and compound 2 showed potent inhibitory activity against both proteases.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Ascomycota / chemistry*
-
Ascomycota / genetics
-
Base Sequence
-
Brazil
-
DNA, Fungal / chemistry
-
Drug Screening Assays, Antitumor
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Pepsin A / antagonists & inhibitors*
-
Rubiaceae / microbiology*
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology
-
Subtilisins / antagonists & inhibitors*
-
Swine
Substances
-
DNA, Fungal
-
Sesquiterpenes
-
xylarenone C
-
xylarenone D
-
xylarenone E
-
Subtilisins
-
Pepsin A